基本情况
胡金辉，男，广东佛山人，中共党员。中山大学药物化学博士，现任五邑大学生物科技与大健康学院专任教师。主要从事多靶点抗阿尔茨海默病(AD)及抗肿瘤药物的研究工作。在Eur. J. Med. Chem.,ACS Chem. Neurosci.,Bioorg. Med. Chem.,Med. Chem.Commun.等国际知名SCI期刊上发表论文10余篇，申请国家发明专利1项。
联系方式
地址：广东省江门市五邑大学生物科技与大健康学院，邮编：529020
工作经历
2019年7月至今，五邑大学，生物科技与大健康学院
教育及学习经历
2017年1月-2017年4月，中山大学药学院药物化学博士学位（硕博连读）
2010年9月-2014年6月，华南农业大学制药工程学士学位
主要研究方向
主要从事多靶点抗阿尔茨海默病(AD)药物的设计、合成和生物活性研究；c-Met激酶抑制剂的设计、合成及抗肿瘤活性研究.
发表学术论文
1.Jinhui Hu, Tingting Pan, Baijiao An, Zhengcunxiao Li, Ling Huang* and Xingshu Li*;Synthesis and evaluation of clioquinol-rolipram/roflumilast hybrids as multitarget-directed ligands for the treatment of Alzheimer’s diseaseEur. J. Med. Chem.,2019, 163(1), 512-526 (IF = 4.82)
2.Jinhui Hu,Ya-Dan Huang, Tingting Pan, Tianhua Zhang, Tao Su, Xingshu Li, Hai-Bin Luo*, and Ling Huang*;Design, synthesis, and biological evaluation of dual-target inhibitors of acetylcholinesterase (AChE) and phosphodiesterase 9A (PDE9A) for the treatment of Alzheimer’s disease,ACS Chem. Neurosci.,2019, 10, 537-551 (IF = 4.21)
3.Jinhui Hu,Baijiao An, Tingting Pan, Zhengcunxiao Li, Ling Huang* and Xingshu Li;Design, synthesis, and biological evaluation of histone deacetylase inhibitors possessing glutathione peroxidase-like and antioxidant activities against Alzheimer’s disease,Bioorg. Med. Chem.,2018, 26(21), 5718-5729(IF = 2.923)
4.Jinhui Hu, Jun Yan, Jie Chen, Yanqing Pang, Ling Huang*,and Xingshu Li*;Synthesis, biological evaluation and mechanism study of a class of benzylideneindanone derivatives as novel anticancer agents,MedChemCommun,2015, 6, 1318-1327 (IF = 2.61)
5. Zhiren Wang,Jinhui Hu, Xiaoping Yang, Xing Feng, Xingshu L*, Ling Huang*, and Albert S. C. Chan;Design, synthesis, and evaluation of orally bioavailable quinoline-indole derivatives as innovative multitarget-directed ligands: promotion of cell proliferation in the adult murine hippocampus for the treatment of Alzheimer's disease,J. Med. Chem.2018, 61, 1871-1894. (IF = 6.25);
6. Jun Yan,Jinhui Hu, Baijiao An, Li Huang, XingshuLi*;Design, synthesis, and biological evaluation of cyclic-indole derivatives as anti-tumor agents via the inhibition of tubulin polymerization,Eur. J. Med. Chem.2017,125,663-675(IF = 4.82);
7. Jun Yan,Jinhui Hu, Anqiu Liu, Lin He, Xingshu Li, Hui Wei*;Design, synthesis, and evaluation of multitarget-directed ligands against Alzheimer’s disease based on the fusion of donepezil and curcumin,Bioorg. Med. Chem.2017, 25, 2946-2955 (IF = 2.923);
8. Chuan-Jun Lu,Jinhui Hu, Zechen Wang, Shishun Xie, Tingting Pan, Ling Huang, Xingshu Li;Discovery of boron-containing compounds as Aβ aggregation inhibitors and antioxidants for the treatment of Alzheimer's disease,MedChemCommun,2018,9, 1862-1870
9. Baijiao An, Bo Wang,Jinhui Hu, Shaoyu Xu, Ling Huang*, Xingshu Li*, and Albert S. C. Chan; Synthesis and biological evaluation of selenium-containing 4-anilinoquinazoline derivatives as novel antimitotic agents,J. Med. Chem.2018, 61, 2571-2588. (IF= 5.59);
10. Baijiao An, Shun Zhang,Jinhui Hu, Tingting Pan, Ling Huang, Johnny Cheuk-on Tang,* Xingshu Li* and Albert S. C. Chan; Synthesis and biological evaluation of selenium-containing 4-anilinoquinazoline derivatives as novel antimitotic agents,Org. Biomol. Chem.2015, 16, 4701-4714.(IF = 3.42);
申请及授权专利
一种新型Tepotinib衍生物和制备方法及其在抗肿瘤药物中的应用(专利申请号：201811059596.7)