基本情况
陈文华,男,教育部新世纪优秀人才,入选全球前2%顶尖科学家榜单“终生科学影响力排行榜”科研人员,教授(三级岗),博士生导师。兼任广东省药学会药物化学专业委员会副主任委员,教育部热带药用植物化学重点实验室(海南师范大学)学术委员会委员,Mini-Reviews in Medicinal Chemistry的Associate Editor以及Bentham科学出版社大使(Bentham Brand Ambassador)。曾留学日本和美国,研究领域为药物化学生物学。先后主持国家自然科学基金面上项目以及教育部新世纪优秀人才支持计划等10余项科研项目,发表英文SCI论文101篇。2008年获Elsevier出版社Bioorganic & Medicinal Chemistry引用次数最多奖,2016年获日本兵库震灾纪念21世纪研究机构兵库海外研究网络(Hyogo Overseas Research Network)事业推进奖。
联系方式
地址: 广东江门市东成村22号 五邑大学 药学与食品工程学院,邮编529020
E-mail: whchen@wyu.edu.cn
教育经历
1994年 四川大学化学系 化学专业学士学位
2000年 日本长崎大学药学院 药物化学专业博士学位
工作经历
2000年4月-2002年3月,日本科学技术振兴机构 博士研究员
2002年4月-2005年10月,中山大学化学与化学工程学院 副教授
2004年7月-2009年8月,美国里海大学化学系 研究科学家
2009年8月-2018年12月,南方医科大学药学院 教授,博士生导师
2019年1月-至今,五邑大学生物科技与大健康学院 教授,博士生导师
讲授课程
本科生:《药物化学》《实验药物化学》《高等药物化学》《有机结构解析》
研究生:《有机波谱分析》
科研方向
1) 基于离子跨膜转运机制的抗肿瘤药物的设计合成及生物活性
2) 生物重要分子的生物传感器的构筑
科研项目
1) 国家自然科学基金面上项目,氟代阴离子转运体的合成及其诱导细胞死亡机制研究,63万元,2019年01月-2022年12月,主持。
2) 江门市科学技术局创新科研团队引进资助项目(新生物功能分子的发现与开发研究创新团队),岭南15种药食同源植物活性物质基础和深度开发研究,600万,2019年01月-2021年12月,第二核心成员。
近三年发表的主要论文
1) X.-H. Yu#, X.-J. Cai#, X.-Q. Hong#, K. Y. Tam, K. Zhang, W.-H. Chen*, “Synthesis and biological evaluation of aza-crown ether-squaramide conjugates as anion/cation symporters”, Future Med. Chem. 2019, DOI: 10.4155/fmc-2018-0595.
2) M.-H. Chen#, Y. Zheng#, X.-J. Cai#, H. Zhang, F.-X. Wang, C.-P. Tan*, W.-H. Chen*, L.-N. Jia, Z.-W. Mao*, “Inhibition of autophagic flux by cyclometalated iridium(III) complexes through anion transportation”, Chem. Sci. 2019, 10 (11), 3315–3323.
3) X.-H. Yu#, X.-Q. Hong#, W.-H. Chen*, “Fluorinated bisbenzimidazoles: a new class of drug-like anion transporters with chloride-mediated, cell apoptosis- inducing activity”, Org. Biomol. Chem. 2019, 17 (6), 1558–1571.
4) X.-Q. Hong, X.-H. Yu, K. Zhang, W.-H. Chen*, “Synthesis and properties of a lysosome-targeting fluorescent ionophore based on coumarins and squaramides”, Org. Biomol. Chem. 2018, 16, 8025–8029.
5) X.-H. Yu, C.-C. Peng, X.-X. Sun, W.-H. Chen*, “Synthesis, anionophoric activity and apoptosis-inducing bioactivity of benzimidazolyl-based transmembrane anion transporters”, Eur. J. Med. Chem. 2018, 152, 115–125.
6) Z. Li, X.-H. Yu, Y. Chen, D.-Q. Yuan and W.-H. Chen*, “Synthesis, anion recognition and transmembrane anionophoric activity of tripodal diaminocholoyl conjugates”, J. Org. Chem. 2017, 82 (24), 13368–13375.
7) Z.-Q. Li, T.-C. Liao, C. Dong, J.-W. Yang, X.-J. Chen, L. Liu, Y. Luo, Y.-Y. Liang, W.-H. Chen* and C.-Q. Zhou*, “Specifically targeting mixed-type dimeric G-quadruplexes using berberine dimers”, Org. Biomol. Chem. 2017, 15 (48), 10221–10229.
8) L. Qin, Z. Sun, K. Cheng, Kai; S.-W. Liu, J. Pang, Jianxin; L.-M. Xia, W.-H. Chen*, Z. Cheng* and J.-X. Chen*, “Zwitterionic manganese and gadolinium metal–organic frameworks as efficient contrast agents for in vivo magnetic resonance imaging”, ACS Appl. Mater. Interfaces 2017, 9 (47), 41378–41386.
9) X. Huang, S. Yasunaga, M. Fukudome, W.-H. Chen*, D.-Q. Yuan*, “A one-pot synthetic method for the hetero-bifunctionalization of α-cyclodextrin at the secondary hydroxyl side with high clockwise–counterclockwise selectivity”, Org. Biomol. Chem. 2017, 15, 4077–4080.
10) X.-J. Cai, Z. Li, W.-H. Chen*, “Tripodal squaramide conjugates as highly effective transmembrane anion transporters”, Bioorg. Med. Chem. Lett. 2017, 27, 1999–2002.
11) Z. Li, Y. Chen, D.-Q. Yuan, W.-H. Chen*, “Synthesis of dimeric 3α-hydroxy-7α,12α- diamino-5β-cholan-24-oate conjugate and its derivatives, and the effect of lipophilicity on their anion-transporting efficacy”, Org. Biomol. Chem. 2017, 15, 2831–2840.
12) C.-C. Peng, M.-J. Zhang, X.-X. Sun, X.-J. Cai, Y. Chen, W.-H. Chen*, “Highly efficient anion transport mediated by 1,3-bis(benzimidazol-2-yl)benzene derivatives bearing electron-withdrawing substituents”, Org. Biomol. Chem. 2016, 14, 8232–8236 (“2016 Hot Articles in Organic and Biomolecular Chemistry”).
13) Z. Li, L.-Q. Deng, Y. Chen, T. Wu, W.-H. Chen*, “Efficient transmembrane anion transport mediated by a bis(imidazolyl)-functionalized bis(choloyl) conjugate”, Bioorg. Med. Chem. Lett. 2016, 26, 3665–3668.
14) C.-C. Chen, Z. Li, L.-Q. Deng, Z.-F. Ke, W.-H. Chen*, “2,6-Bis(benzimidazol-2-yl) pyridine as a potent transmembrane anion transporter”, Bioorg. Med. Chem. Lett. 2016, 26, 2442–2445.
15) S. Zheng, S. Zhong, Z. Chen, W. Chen*, Q. Zhu*, “Efficient synthesis of a series of novel octahydroquinazoline-5-ones via a simple on-water urea-catalyzed chemoselective five-component reaction”, ACS Comb. Sci. 2016, 18 (8), 475–481.
16) H.-Q. Zhao, S.-P. Yang, N. Ding, L. Qin, G.-H. Qiu, J.-X. Chen*, W.-H. Zhang*, W.-H. Chen* and T. S. A. Hor*, “A zwitterionic 1D/2D polymer co-crystal and its polymorphic sub-components: a highly selective sensing platform for HIV ds-DNA sequences”, Dalton Trans. 2016, 45, 5092–5100.
17) C.-Q. Zhou, J.-W. Yang, C. Dong, Y.-M. Wang, B. Sun, J.-X. Chen, Y.-S. Xu, W.-H. Chen*, “Highly selective, sensitive and fluorescent sensing of dimeric G-quadruplexes by a dimeric berberine”, Org. Biomol. Chem. 2016, 14, 191–197.
18) L. Qin, L.-X. Lin, Z.-P. Fang, S.-P. Yang, G.-H. Qiu, J.-X. Chen* and W.-H. Chen*, “A water-stable metal–organic framework of a zwitterionic carboxylate with dysprosium: a sensing platform for Ebolavirus RNA sequences”, Chem. Commun. 2016, 52, 132–135.